Plant geranylgeranyl diphosphate synthases: every (gene) family has a story
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چکیده
منابع مشابه
Geranylgeranyl diphosphate synthases from Scoparia dulcis and Croton sublyratus. cDNA cloning, functional expression, and conversion to a farnesyl diphosphate synthase.
cDNAs encoding geranylgeranyl diphosphate synthase (GGPPS) of two diterpene producing plants, Scoparia dulcis and Croton sublyratus, were isolated using the homology-based polymerase chain reaction method. Both cloned genes showed high amino acid sequence homology (60-70%) to other plant GGPPSs and contained highly conserved aspartate-rich motifs. The obtained clones were functionally expressed...
متن کاملFive geranylgeranyl diphosphate synthases expressed in different organs are localized into three subcellular compartments in Arabidopsis.
Geranylgeranyl diphosphate (GGPP) is the precursor for the biosynthesis of gibberellins, carotenoids, chlorophylls, isoprenoid quinones, and geranylgeranylated proteins in plants. There is a small gene family for GGPP synthases encoding five isozymes and one related protein in Arabidopsis, and all homologs have a putative localization signal to translocate into specific subcellular compartments...
متن کاملBisphosphonates induce autophagy by depleting geranylgeranyl diphosphate.
Multiple studies have implicated the depletion of isoprenoid biosynthetic pathway intermediates in the induction of autophagy. However, the exact mechanism by which isoprenoid biosynthesis inhibitors induce autophagy has not been well established. We hypothesized that inhibition of farnesyl diphosphate synthase (FDPS) and geranylgeranyl diphosphate synthase (GGDPS) by bisphosphonates would indu...
متن کاملA Picture for Every Story
"Chascune hystoire est d'ymage illustree," wrote Gilles Corrozet towards the end of the introduction to his emblem book, Hecatongraphie, published in Paris in I543. He had begun by saying that the chief aims he had in mind when writing his little moral stories were pleasure and instruction but that pictures had been added to make his ideas more vivid; these would also be useful to people other ...
متن کاملModification of Rab5 with a photoactivatable analog of geranylgeranyl diphosphate.
A photoprobe analog of geranylgeranyl diphosphate (2-diazo-3,3,3-trifluoropropionyloxy-farnesyl diphosphate or DATFP-FPP) inhibits mevalonate-dependent prenylation of in vitro translated Rab5 in rabbit reticulocyte lysate, suggesting that it competes for lipid binding to the Rab geranylgeranyl transferase. Modification of Rab5 with DATFP-FPP, demonstrated by gel mobility shift and Triton X-114 ...
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ژورنال
عنوان ژورنال: aBIOTECH
سال: 2021
ISSN: 2096-6326,2662-1738
DOI: 10.1007/s42994-021-00050-5